Creatine and the bigger picture
During high-intensity exercise, the body uses phosphocreatine to help regenerate ATP quickly. That is why creatine is so well known in sports nutrition. At the same time, performance depends on more than ATP alone. Working muscle also depends on mitochondrial function, oxygen-related processes, and the ability to stay balanced when oxidative stress rises during repeated effort.
What CreaSol® SSAT is designed to support
• A better cellular environment during hard effort
• Mitochondrial function linked with efficient energy use
• Oxygen-related pathways that support working muscle
• Oxidative balance and resilience under training stress
Human research
A 4-week randomized, double-blind, placebo-controlled trial (n = 48 healthy adults) investigated the effects of CreaSol® SSAT (500 mg/day) combined with a low dose of creatine (3 g/day, no loading phase) compared to creatine alone, tyrosol alone, and placebo.
Study link:
Key findings:
5-RM Bench Press Performance:
· The CreaSol® + Creatine group significantly increased 5-RM bench press repetitions by 20.8% (p < 0.001) and training volume by 25.5% (p < 0.001) from baseline.
· The increase in repetitions was significantly greater than the Creatine-only group (p = 0.02), and the increase in training volume was also significantly greater than the Creatine-only group (p = 0.03).
· CreaSol® + Creatine showed 7.8X greater training volume gains compared to creatine alone
50% 1-RM Bench Press Performance:
· The CreaSol® + Creatine group significantly increased training volume at 50% 1-RM by 18.8% (p = 0.002), with a trend toward increased repetitions (+12.4%, p = 0.052).
· The increase in training volume was significantly greater than the Creatine-only group (p = 0.042).
These findings demonstrate that combining CreaSol® SSAT with a low dose of creatine enhances high-intensity resistance training performance in a short period, with effects superior to creatine alone.
Dosage Study: Effective at Just 150mg
To further optimize the dosage for different creatine product applications, we conducted a dose-ranging study for CreaSol® using a reverse-translational framework applied in pharmaceutical R&D. This approach uses established clinical findings to guide subsequent preclinical dose evaluation and can incorporate both dose-response and longitudinal effects to support dose and duration selection.
Results:
Muscle Endurance:
500 mg CreaSol® + 5 g creatine
→ 52.4% better than creatine alone, 4 weeks
150 mg CreaSol® + 5 g creatine
→ 41.6% better, 6 weeks
→ 69.6% better, 8 weeks
Muscle Strength:
500 mg CreaSol® + 5 g creatine
→ 7.7% better than creatine alone, 4 weeks
150 mg CreaSol® + 5 g creatine
→ 16.1% better at, 6 weeks
→ 17.0% better at, 8 weeks
These results support 150 mg as a scientifically justified lower-dose option for longer-term supplementation.
